Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling.
- Yap MS Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
- Nathan KR Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
- Yeo Y Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
- Lim LW Department of Physiology, The University of Hong Kong, Pokfulam, Hong Kong.
- Poh CL Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
- Richards M School of Chemical & Life Sciences, Nanyang Polytechnic, 180 Ang Mo Kio Avenue 8, Singapore 569830.
- Lim WL Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
- Othman I Jeffrey Cheah School of Medicine, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
- Heng BC Department of Biological Sciences, Faculty of Science & Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia ; Department of Physiology, The University of Hong Kong, Pokfulam, Hong Kong ; Department of Biosystems Science & Engineering (D-BSSE), ETH-Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
- 2015-06-20
Published in:
- Stem cells international. - 2015
English
Human pluripotent stem cells (hPSCs) derived from either blastocyst stage embryos (hESCs) or reprogrammed somatic cells (iPSCs) can provide an abundant source of human neuronal lineages that were previously sourced from human cadavers, abortuses, and discarded surgical waste. In addition to the well-known potential therapeutic application of these cells in regenerative medicine, these are also various promising nontherapeutic applications in toxicological and pharmacological screening of neuroactive compounds, as well as for in vitro modeling of neurodegenerative and neurodevelopmental disorders. Compared to alternative research models based on laboratory animals and immortalized cancer-derived human neural cell lines, neuronal cells differentiated from hPSCs possess the advantages of species specificity together with genetic and physiological normality, which could more closely recapitulate in vivo conditions within the human central nervous system. This review critically examines the various potential nontherapeutic applications of hPSC-derived neuronal lineages and gives a brief overview of differentiation protocols utilized to generate these cells from hESCs and iPSCs.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1155/2015/105172
- PMID 26089911
- Persistent URL
- https://sonar.ch/global/documents/140119
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