Journal article
Validity of SYNTAX score II for risk stratification of percutaneous coronary interventions: A patient-level pooled analysis of 5,433 patients enrolled in contemporary coronary stent trials.
- Campos CM Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands; Department of Interventional Cardiology Heart Institute (InCor), University of São Paulo Medical School, Sao Paulo, Brazil.
- Garcia-Garcia HM Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands; Cardialysis, Rotterdam, The Netherlands. Electronic address: h.garciagarcia@erasmusmc.nl.
- van Klaveren D Department of Public Health, Erasmus MC - University Medical Centre Rotterdam, Rotterdam, The Netherlands.
- Ishibashi Y Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands.
- Cho YK Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands.
- Valgimigli M Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands.
- Räber L Department of Cardiology, Bern University Hospital, Bern, Switzerland.
- Jonker H Cardialysis, Rotterdam, The Netherlands.
- Onuma Y Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands.
- Farooq V Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands.
- Garg S Department of Cardiology, East Lancashire Hospitals NHS Trust, Blackburn, United Kingdom.
- Windecker S Department of Cardiology, Bern University Hospital, Bern, Switzerland.
- Morel MA Cardialysis, Rotterdam, The Netherlands.
- Steyerberg EW Department of Public Health, Erasmus MC - University Medical Centre Rotterdam, Rotterdam, The Netherlands.
- Serruys PW Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands; International Centre for Circulatory Health, NHLI, Imperial College London, London, United Kingdom.
- 2015-04-02
Published in:
- International journal of cardiology. - 2015
Drug-eluting stent
Percutaneous coronary intervention
Risk stratification
SYNTAX score
SYNTAX score II
Coronary Artery Disease
Drug-Eluting Stents
Female
Follow-Up Studies
Global Health
Humans
Male
Middle Aged
Percutaneous Coronary Intervention
Survival Rate
Time Factors
Treatment Outcome
English
OBJECTIVES
To assess the clinical profile and long-term mortality in SYNTAX score II based strata of patients who received percutaneous coronary interventions (PCI) in contemporary randomized trials.
BACKGROUND
The SYNTAX score II was developed in the randomized, all-comers' SYNTAX trial population and is composed by 2 anatomical and 6 clinical variables. The interaction of these variables with the treatment provides individual long-term mortality predictions if a patient undergoes coronary artery bypass grafting (CABG) or PCI.
METHODS
Patient-level (n=5433) data from 7 contemporary coronary drug-eluting stent (DES) trials were pooled. The mortality for CABG or PCI was estimated for every patient. The difference in mortality estimates for these two revascularization strategies was used to divide the patients into three groups of theoretical treatment recommendations: PCI, CABG or PCI/CABG (the latter means equipoise between CABG and PCI for long term mortality).
RESULTS
The three groups had marked differences in their baseline characteristics. According to the predicted risk differences, 5115 patients could be treated either by PCI or CABG, 271 should be treated only by PCI and, rarely, CABG (n=47) was recommended. At 3-year follow-up, according to the SYNTAX score II recommendations, patients recommended for CABG had higher mortality compared to the PCI and PCI/CABG groups (17.4%; 6.1% and 5.3%, respectively; P<0.01).
CONCLUSIONS
The SYNTAX score II demonstrated capability to help in stratifying PCI procedures.
To assess the clinical profile and long-term mortality in SYNTAX score II based strata of patients who received percutaneous coronary interventions (PCI) in contemporary randomized trials.
BACKGROUND
The SYNTAX score II was developed in the randomized, all-comers' SYNTAX trial population and is composed by 2 anatomical and 6 clinical variables. The interaction of these variables with the treatment provides individual long-term mortality predictions if a patient undergoes coronary artery bypass grafting (CABG) or PCI.
METHODS
Patient-level (n=5433) data from 7 contemporary coronary drug-eluting stent (DES) trials were pooled. The mortality for CABG or PCI was estimated for every patient. The difference in mortality estimates for these two revascularization strategies was used to divide the patients into three groups of theoretical treatment recommendations: PCI, CABG or PCI/CABG (the latter means equipoise between CABG and PCI for long term mortality).
RESULTS
The three groups had marked differences in their baseline characteristics. According to the predicted risk differences, 5115 patients could be treated either by PCI or CABG, 271 should be treated only by PCI and, rarely, CABG (n=47) was recommended. At 3-year follow-up, according to the SYNTAX score II recommendations, patients recommended for CABG had higher mortality compared to the PCI and PCI/CABG groups (17.4%; 6.1% and 5.3%, respectively; P<0.01).
CONCLUSIONS
The SYNTAX score II demonstrated capability to help in stratifying PCI procedures.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.ijcard.2015.03.248
- PMID 25828327
- Persistent URL
- https://sonar.ch/global/documents/140345
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