Apoptosis: bombarding the mitochondria.
- Parone P Department of Cell Biology, University of Geneva, 30 quai Ansermet, 1211 Geneva 4, Switzerland.
- Priault M
- James D
- Nothwehr SF
- Martinou JC
- 2003-10-31
Published in:
- Essays in biochemistry. - 2003
Animals
Apoptosis
Caenorhabditis elegans
Gene Expression Regulation
Mitochondria
Models, Biological
Oxygen
Proto-Oncogene Proteins c-bcl-2
English
Mitochondria play a central role in apoptosis triggered by many stimuli. They integrate death signals through Bcl-2 family members and co-ordinate caspase activation through the release of apoptogenic factors that are normally sequestered in the mitochondrial intermembrane space. The release of these proteins is the result of the outer mitochondrial membrane becoming permeable. In addition, mitochondria can initiate apoptosis through the production of reactive oxygen species.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1042/bse0390041
- PMID 14585073
- Persistent URL
- https://sonar.ch/global/documents/1405
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