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To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.

  • Boeltz S Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
  • Amini P Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Anders HJ Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
  • Andrade F Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Bilyy R Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
  • Chatfield S Inflammation Division, Walter and Eliza Hall Institute, Melbourne, Victoria, Australia.
  • Cichon I Department of Experimental Hematology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.
  • Clancy DM VIB-UGent Center for Inflammation Research, University of Gent, Gent, Belgium.
  • Desai J Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
  • Dumych T Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
  • Dwivedi N Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Gordon RA Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Hahn J Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
  • Hidalgo A Department of Cell and Developmental Biology, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.
  • Hoffmann MH Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany. markus.hoffmann@uk-erlangen.de.
  • Kaplan MJ Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, USA.
  • Knight JS Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.
  • Kolaczkowska E Department of Experimental Hematology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.
  • Kubes P Snyder institute of Chronic Diseases, University of Calgary, Calgary, Canada.
  • Leppkes M Department of Medicine 1 - Gastroenterology, Pulmonology and Endocrinology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Manfredi AA Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy.
  • Martin SJ Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland.
  • Maueröder C Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
  • Maugeri N Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy.
  • Mitroulis I Laboratory of Molecular Hematology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Munoz LE Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
  • Nakazawa D Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
  • Neeli I Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Nizet V UC San Diego School of Medicine, La Jolla, CA, USA.
  • Pieterse E Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Radic MZ Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Reinwald C Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
  • Ritis K Laboratory of Molecular Hematology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Rovere-Querini P Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy.
  • Santocki M Department of Experimental Hematology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.
  • Schauer C Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
  • Schett G Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
  • Shlomchik MJ Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Simon HU Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Skendros P Laboratory of Molecular Hematology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Stojkov D Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Vandenabeele P VIB-UGent Center for Inflammation Research, University of Gent, Gent, Belgium.
  • Berghe TV VIB-UGent Center for Inflammation Research, University of Gent, Gent, Belgium.
  • van der Vlag J Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Vitkov L Department of Biosciences, Vascular & Exercise Biology Unit, University of Salzburg, Salzburg, Austria.
  • von Köckritz-Blickwede M Department of Physiological Chemistry & Research Center for Emerging Infections and Zoonosis (RIZ), University of Veterinary Medicine Hannover, Hannover, Germany.
  • Yousefi S Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Zarbock A University of Münster, Department of Anesthesiology, Intensive Care and Pain Medicine, Münster, Germany.
  • Herrmann M Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
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  • 2019-01-10
Published in:
  • Cell death and differentiation. - 2019
Extracellular Traps
Humans
Neutrophils
English Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/140802
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