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Targeted delivery of polyoxometalate nanocomposites.
Journal article

Targeted delivery of polyoxometalate nanocomposites.

  • 2011-09-29
Published in:
  • Small (Weinheim an der Bergstrasse, Germany). - 2011
Cell Death
Chitosan
Drug Delivery Systems
HeLa Cells
Humans
Microscopy, Confocal
Nanocomposites
Spectroscopy, Fourier Transform Infrared
Tungsten Compounds
English Polyoxometalate/carboxymethyl chitosan nanocomposites with an average diameter of 130 nm are synthesized and labeled with fluorescein isothiocyanate (FITC) for a combined drug-carrier and cellular-monitoring approach. [Eu(β(2) -SiW(11) O(39) )(2) ](13-) /CMC nanospheres as a representative example do not display cytotoxicity for POM concentrations up to 2 mg mL(-1) . Cellular uptake of fluoresecently labelled {EuSiW(11) O(39) }/FITC-CMC nanoparticles is monitored with confocal laser scanning microscopy. Nanoparticle uptake occurs after incubation times of around 1 h and no cyctotoxic effects are observed upon prolonged treatment. The preferential location of the POM/CMC nanocomposites in the perinuclear region is furthermore verified with transmission electron microscopy investigations on unlabeled nanoparticles. Therefore, this approach is a promising dual strategy for the safe cellular transfer and monitoring of bioactive POMs.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/141868
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