Journal article

Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.

  • Levine DJ Pulmonary Disease and Critical Care Medicine, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
  • Glanville AR The Lung Transplant Unit, St. Vincent's Hospital, Sydney, New South Wales, Australia. Electronic address: allan.glanville@svha.org.au.
  • Aboyoun C The Lung Transplant Unit, St. Vincent's Hospital, Sydney, New South Wales, Australia.
  • Belperio J Pulmonary Disease and Critical Care Medicine, University of California, Los Angeles, California, USA.
  • Benden C Division of Pulmonary Medicine, University Hospital Zurich, Zurich, Switzerland.
  • Berry GJ Division of Pathology, Stanford University Medical Center, Palo Alto, California, USA.
  • Hachem R Division of Pulmonology, Washington University, St. Louis, Missouri, USA.
  • Hayes D Department of Pulmonology, The Ohio State University, Columbus, Ohio, USA.
  • Neil D Department of Pathology, Queen Elizabeth Hospital, Birmingham, UK.
  • Reinsmoen NL Department of Immunology, Cedars-Sinai Hospital, Los Angeles, California, USA.
  • Snyder LD Department of Pulmonology, Duke University, Durham, North Carolina, USA.
  • Sweet S Division of Pulmonology, Washington University, St. Louis, Missouri, USA.
  • Tyan D Division of Pathology, Stanford University Medical Center, Palo Alto, California, USA.
  • Verleden G Department of Pulmonology, University Hospitals Leuven, Leuven, Belgium.
  • Westall G Department of Pulmonology, Alfred Hospital, Melbourne, Victoria, Australia.
  • Yusen RD Division of Pulmonology, Washington University, St. Louis, Missouri, USA.
  • Zamora M Department of Pulmonology, University of Colorado, Denver, Colorado, USA.
  • Zeevi A Department of Immunology, University of Pittsburgh, Pittsburgh, Pennyslvania, USA.
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  • 2016-04-06
Published in:
  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. - 2016
English Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no standardized diagnostic criteria or an agreed-upon definition. Hence, a working group was created by the International Society for Heart and Lung Transplantation with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed toward donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or sub-clinical (normal allograft function). This consensus definition will have clinical, therapeutic and research implications.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/142236
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