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Size distribution of spontaneously formed liposomes by the alcohol injection method.
Journal article

Size distribution of spontaneously formed liposomes by the alcohol injection method.

  • Domazou AS Institute of Polymers, ETH-Zentrum, Zürich, CH-8092, Switzerland. adomazou@ifp.mat.ethz.ch
  • Luisi PL
  • 2003-02-27
Published in:
  • Journal of liposome research. - 2002
Aging
Alcohols
Chemical Phenomena
Chemistry, Physical
Drug Stability
Hydrogen-Ion Concentration
Liposomes
Particle Size
Phosphatidylcholines
Solutions
Water
English A dynamic light scattering study of the size distribution of POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) liposomes formed by the injection method is presented. By this method, an aliquot of methanol stock solution containing the surfactant is injected into water. The main aim of the present work was to determine under which conditions a monomodal and narrow size distribution could be obtained. The influence of several parameters on the size distribution was investigated. Firstly, we examined the influence of the POPC concentration in the initial stock methanol solution, when the POPC concentration in the final aqueous solution remains constant; secondly, the influence of POPC concentration in the aqueous phase, while the lipid concentration in the stock methanol remains constant. In both cases narrow monomodal size distributions of liposomes, centered between 40 and 70 nm, are obtained at low concentrations of POPC, in the stock methanol solution (
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/142532
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