Journal article
Oligosaccharide synthesis in microreactors.
- Carrel FR Laboratory of Organic Chemistry, Swiss Federal Institute of Technology ETH Zürich, Zürich, Switzerland.
- Geyer K
- Codée JD
- Seeberger PH
- 2007-05-11
Published in:
- Organic letters. - 2007
English
Described is the combination of microreactors and fluorous phase chemistry to assemble oligosaccharides. The synthesis of a beta-(1-->6) linked D-glucopyranoside homotetramer serves to illustrate this approach. Glycosylations employing a Fmoc-protected glucosyl phosphate building block were performed in a silicon-based micro-structured device to optimize reaction conditions and for reaction scale-up. A perfluorinated linker at the reducing end of the oligosaccharides allowed for purification by fluorous solid-phase extraction (FSPE) and further functionalization.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ol0705503
- PMID 17489597
- Persistent URL
- https://sonar.ch/global/documents/142594
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