Journal article
Probing glycomics.
- Timmer MS Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, Wolfgang-Pauli Strasse 10, 8093 Zurich, Switzerland.
- Stocker BL
- Seeberger PH
- 2007-01-09
Published in:
- Current opinion in chemical biology. - 2007
Carbohydrate Conformation
Carbohydrate Sequence
Glycosylation
Heparin
Lactose
Microarray Analysis
Molecular Probes
Molecular Sequence Data
Polysaccharides
Protein Binding
Proteins
English
The study of protein-carbohydrate interactions is one central theme of glycomics research. The challenges encountered when investigating these interactions have resulted in an approach that studies saccharides through the enzymes that process them. Proteins and their function are often probed by manipulating the genes that encode them. Efforts in proteoglycomics exploring protein-binding properties and the enzymatic modification of carbohydrates have intensified, and synthetic tools, including activity- and affinity-based probes, have enhanced our understanding of the roles of carbohydrates in biology.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.cbpa.2006.11.040
- PMID 17208037
- Persistent URL
- https://sonar.ch/global/documents/142644
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