Journal article
Neurophysiological correlates of Avolition-apathy in schizophrenia: A resting-EEG microstates study.
- Giordano GM Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
- Koenig T Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
- Mucci A Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy. Electronic address: armida.mucci@gmail.com.
- Vignapiano A Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
- Amodio A Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
- Di Lorenzo G Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
- Siracusano A Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
- Bellomo A Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
- Altamura M Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
- Monteleone P Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Section of Neurosciences, University of Salerno, Salerno, Italy.
- Pompili M Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant' Andrea Hospital, Sapienza University of Rome, Rome.
- Galderisi S Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
- Maj M Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
- 2018-09-12
Published in:
- NeuroImage. Clinical. - 2018
Anhedonia
Avolition-apathy
Brain electrical microstates
Resting-EEG
Schizophrenia
Adult
Anhedonia
Apathy
Brain
Electroencephalography
Female
Humans
Male
Middle Aged
Rest
Schizophrenia
Schizophrenic Psychology
Young Adult
English
Background
The "Avolition-apathy" domain of the negative symptoms was found to include different symptoms by factor analytic studies on ratings derived by different scales. In particular, the relationship of anhedonia with this domain is controversial. Recently introduced negative symptom rating scales provide a better assessment of anhedonia, allowing the distinction of anticipatory and consummatory aspects, which might be related to different psychopathological dimensions. The study of associations with external validators, such as electrophysiological, brain imaging or cognitive indices, might shed further light on the status of anhedonia within the Avolition-apathy domain.
Objectives
We used brain electrical microstates (MSs), which represent subsecond periods of quasi-stable scalp electrical field, associated with resting-state neural networks (and thus with global patterns of functional connectivity), to test whether the component symptoms of Avolition-apathy share the same correlates.
Method
We analyzed multichannel resting EEGs in 142 individuals with schizophrenia (SCZ) and in 64 healthy controls (HC), recruited within the add-on EEG study of the Italian Network for Research on Psychoses. Relative time contribution, duration and occurrence of four MS classes (MS-A/-B/-C/-D) were calculated. Group differences on MS parameters (contribution and duration) and their associations with negative symptom domains (assessed using the Brief Negative Symptoms Scale) were investigated.
Results
SCZ, in comparison to HC, showed increased contribution and duration of MS-C. The contribution of MS-A positively correlated with Avolition-apathy, but not with Expressive deficit. Within the Avolition-apathy domain, anticipatory anhedonia, avolition and asociality, but not consummatory anhedonia, showed the same correlations with MS-A contribution.
Conclusion
Our findings support the existence of distinct electrophysiological correlates of Avolition-apathy with respect to Expressive deficit, and lend support to the hypothesis that only the anticipatory component of anhedonia shares the same pathophysiological underpinnings of the Avolition-apathy domain.
The "Avolition-apathy" domain of the negative symptoms was found to include different symptoms by factor analytic studies on ratings derived by different scales. In particular, the relationship of anhedonia with this domain is controversial. Recently introduced negative symptom rating scales provide a better assessment of anhedonia, allowing the distinction of anticipatory and consummatory aspects, which might be related to different psychopathological dimensions. The study of associations with external validators, such as electrophysiological, brain imaging or cognitive indices, might shed further light on the status of anhedonia within the Avolition-apathy domain.
Objectives
We used brain electrical microstates (MSs), which represent subsecond periods of quasi-stable scalp electrical field, associated with resting-state neural networks (and thus with global patterns of functional connectivity), to test whether the component symptoms of Avolition-apathy share the same correlates.
Method
We analyzed multichannel resting EEGs in 142 individuals with schizophrenia (SCZ) and in 64 healthy controls (HC), recruited within the add-on EEG study of the Italian Network for Research on Psychoses. Relative time contribution, duration and occurrence of four MS classes (MS-A/-B/-C/-D) were calculated. Group differences on MS parameters (contribution and duration) and their associations with negative symptom domains (assessed using the Brief Negative Symptoms Scale) were investigated.
Results
SCZ, in comparison to HC, showed increased contribution and duration of MS-C. The contribution of MS-A positively correlated with Avolition-apathy, but not with Expressive deficit. Within the Avolition-apathy domain, anticipatory anhedonia, avolition and asociality, but not consummatory anhedonia, showed the same correlations with MS-A contribution.
Conclusion
Our findings support the existence of distinct electrophysiological correlates of Avolition-apathy with respect to Expressive deficit, and lend support to the hypothesis that only the anticipatory component of anhedonia shares the same pathophysiological underpinnings of the Avolition-apathy domain.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1016/j.nicl.2018.08.031
- PMID 30202724
- Persistent URL
- https://sonar.ch/global/documents/142647
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