Tenascin-C induced signaling in cancer.

Orend G; Chiquet-Ehrismann R

doi:10.1016/j.canlet.2006.02.017

Back

Journal article

Tenascin-C induced signaling in cancer.

Orend G Department of Clinical and Biological Sciences, Institute of Biochemistry and Genetics, Center for Biomedicine, DKBW, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland. gertraud.orend@unibas.ch
Chiquet-Ehrismann R

2006-04-25

Published in:

Cancer letters. - 2006

English Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed in the microenvironment of most solid tumors. High tenascin-C expression reduces the prognosis of disease-free survival in patients with some cancers. The possible role of tenascin-C in tumor initiation and progression is addressed with emphasis on underlying signaling mechanisms. How tenascin-C affects malignant transformation, uncontrolled proliferation, angiogenesis, metastasis and escape from tumor immunosurveillance is summarized. Finally, we discuss how the phenotypes of tenascin-C knock-out mice may help define the roles of tenascin-C in tumorigenesis and how this knowledge could be applied to cancer therapy.

Language