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Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids.
Journal article

Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids.

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  • 2011-07-27
Published in:
  • Journal of agricultural and food chemistry. - 2011
Animals
Antimalarials
Antiprotozoal Agents
Cell Line
Cell Survival
Chrysanthemum cinerariifolium
Flowers
Myoblasts, Skeletal
Plant Extracts
Plasmodium falciparum
Pyrethrins
Rats
Trypanosoma brucei rhodesiense
English In a screen of 1800 plant and fungal extracts for antiplasmodial, antitrypanosomal, and leishmanicidal activity, the n-hexane extract of Chrysanthemum cinerariifolium (Trevir.) Vis. flowers showed strong activity against Plasmodium falciparum. We isolated the five pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and jasmolin I (5)] from this extract. These were tested together with 15 synthetic pyrethroids for their activity against P. falciparum and Trypanosoma brucei rhodesiense and for cytotoxicity in rat myoblast L6 cells. The natural pyrethrins showed antiplasmodial activity with IC(50)s between 4 and 12 μM, and antitrypanosomal activity with IC(50)s from 7 to 31 μM. The pyrethroids exhibited weaker antiplasmodial and antitrypanosomal activity than the pyrethrins. Both pyrethrins and pyrethroids showed moderate cytotoxicity against L6 cells. Pyrethrin II (1) was the most selective antiplasmodial compound, with a selectivity index of 24.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/143247
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