Journal article
Synthesis of α-CF3-substituted carbonyl compounds with relative and absolute stereocontrol using electrophilic CF3-transfer reagents.
- Matoušek V Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, CH-8093 Zürich, Switzerland.
- Togni A
- Bizet V
- Cahard D
- 2011-10-04
Published in:
- Organic letters. - 2011
English
Evans-type chiral lithium imide enolates undergo diastereoselective α-trifluoromethylation with a hypervalent iodine-CF(3) reagent with up to 91% combined isolated yield and 97:3 dr. The resulting isolated diastereopure products can be further transformed into valuable products without racemization.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ol2023328
- PMID 21962226
- Persistent URL
- https://sonar.ch/global/documents/143314
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