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Absence of experimental evidence of a delta-shock in the system phenetole and 4-tert-butylphenol on Zorbax 300SB-C18.
Journal article

Absence of experimental evidence of a delta-shock in the system phenetole and 4-tert-butylphenol on Zorbax 300SB-C18.

  • Jermann S Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland.
  • Ortner F Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland.
  • Rajendran A Faculty of Engineering, Department of Chemical and Materials Engineering, University of Alberta, 9107-116 Street, Edmonton, AB T6G 2V4, Canada.
  • Mazzotti M Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland. Electronic address: marco.mazzotti@ipe.mavt.ethz.ch.
  • 2015-11-29
Published in:
  • Journal of chromatography. A. - 2015
Delta-shock
Non-linear chromatography
Adsorption
Chemistry Techniques, Analytical
Chromatography
Computer Simulation
Methanol
Phenols
Phenyl Ethers
Water
English We investigate the system consisting of phenetole (PNT) and 4-tert-butylphenol (TBP) in methanol-water (63:37 v:v) on a Zorbax 300SB-C18 column by characterising single component isotherms, by performing a large number of binary experiments of different types and by describing the experiments through simulations carried out using a novel, rather powerful competitive adsorption isotherm, that we call the generalized bi-Langmuir isotherm. This system is of great interest because it was previously reported to yield a new type of transition in nonlinear chromatography, the so-called delta-shock. Such transition had been discovered earlier through a theoretical analysis and confirmed by detailed simulations. The initial aim of this work was to reach a satisfactory agreement between delta-shock experiments and corresponding numerical simulations. In the course of this work however, a number of inconsistencies in the interpretation of the previous experimental results were highlighted and explained. This led to a new experimental campaign, which is reported here and has allowed to reach two important conclusions: (1) The binary system PNT-TBP mentioned above does not exhibit a delta-shock; the spike in the UV profile, which has previously been interpreted as an experimental evidence of the delta-shock, results from liquid-liquid phase separation within the chromatographic column. (2) The same system exhibits a rather peculiar behavior in breakthrough and displacement experiments, which could be well described using the generalized bi-Langmuir isotherm.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/143396
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