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Multiplexed Point-of-Care Testing - xPOCT.

  • Dincer C University of Freiburg, Department of Microsystems Engineering (IMTEK), Laboratory for Sensors, Georges-Koehler-Allee 103, 79110 Freiburg, Germany; University of Freiburg, Freiburg Materials Research Center (FMF), Stefan-Meier-Straße 21, 79104 Freiburg, Germany. Electronic address: dincer@imtek.de.
  • Bruch R University of Freiburg, Department of Microsystems Engineering (IMTEK), Laboratory for Sensors, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
  • Kling A ETH Zurich, Department of Biosystems Science and Engineering, Bioanalytics Group, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Dittrich PS ETH Zurich, Department of Biosystems Science and Engineering, Bioanalytics Group, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Urban GA University of Freiburg, Department of Microsystems Engineering (IMTEK), Laboratory for Sensors, Georges-Koehler-Allee 103, 79110 Freiburg, Germany; University of Freiburg, Freiburg Materials Research Center (FMF), Stefan-Meier-Straße 21, 79104 Freiburg, Germany.
  • 2017-05-01
Published in:
  • Trends in biotechnology. - 2017
lab-on-a-chip (LOC)
microfluidics
multianalyte analysis
multiplexing
on-site testing
point-of-care testing (POCT)
Animals
Humans
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques
Point-of-Care Systems
English Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors' offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the present diagnostic systems and techniques for xPOCT applications. Different multiplexing technologies (e.g., bead- or array-based systems) are considered along with their detection methods (e.g., electrochemical or optical). We also address the unmet needs and challenges of xPOCT. Finally, we critically summarize the in-field applicability and the future perspectives of the presented approaches.
Language
  • English
Open access status
hybrid
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Persistent URL
https://sonar.ch/global/documents/143680
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