Journal article
The evolution and rise of stereotactic body radiotherapy (SBRT) for spinal metastases.
- Vellayappan BA a Department of Radiation Oncology , National University Cancer Institute Singapore, National University Health System , Singapore.
- Chao ST b Department of Radiation Oncology , Cleveland Clinic , Cleveland , OH , USA.
- Foote M c Department of Radiation Oncology , Princess Alexandra Hospital , Brisbane , Queensland , Australia.
- Guckenberger M d Department of Radiation Oncology , University Hospital Zurich, University of Zurich , Zurich , Switzerland.
- Redmond KJ e Department of Radiation Oncology and Molecular Radiation Sciences , The Johns Hopkins University , Baltimore , MD , USA.
- Chang EL f Department of Radiation Oncology , University of Southern California, Keck School of Medicine , Los Angeles , CA , USA.
- Mayr NA g Department of Radiation Oncology , University of Washington School of Medicine , Seattle , WA , USA.
- Sahgal A h Department of Radiation Oncology , Sunnybrook Health Sciences Centre, University of Toronto , Toronto , ON , Canada.
- Lo SS g Department of Radiation Oncology , University of Washington School of Medicine , Seattle , WA , USA.
- 2018-06-27
Published in:
- Expert review of anticancer therapy. - 2018
Spinal metastases
oligo-metastases
radiosurgery
radiotherapy
stereotactic body radiotherapy
Humans
Imaging, Three-Dimensional
Patient Selection
Practice Guidelines as Topic
Radiosurgery
Re-Irradiation
Spinal Neoplasms
Treatment Outcome
English
Owing to improvements in clinical care and systemic therapy, more patients are being diagnosed with, and living longer with, spinal metastases (SM). In parallel, tremendous technological progress has been made in the field of radiation oncology. Advances in both software and hardware are able to integrate three- (and four-) dimensional body imaging with spatially accurate treatment delivery methods. This leads to improved efficacy, shortened treatment schedule, and potentially reduced treatment-related toxicity. Areas covered: In this review, we will look at the progress made by stereotactic body radiotherapy (SBRT) in the management of SM. We will review the technological factors which have enabled the widespread use of SBRT. The efficacy of SBRT, in various clinical scenarios, and associated toxicities will be reviewed. Lastly, we will discuss about patient selection and provide a five-year roadmap. Expert commentary: Spine SBRT is a safe and efficacious treatment option. Practice guidelines recommend the use of SBRT in oligometastatic patients especially those with radio-resistant cancer types, and in scenarios involving re-irradiation. SBRT offers patients dose-intensification over a short schedule which may allow less time off systemic therapy. The results of the phase III trials are eagerly awaited.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1080/14737140.2018.1493381
- PMID 29940802
- Persistent URL
- https://sonar.ch/global/documents/144303
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