Journal article
The “RENAISSANCE” Trial: Effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction—A phase III trial of the German AIO/CAO-V/CAOGI.
- Mueller, Daniel Wilhelm Institute of Clinical Cancer Research (IKF) at Krankenhaus Nordwest, UCT-University Cancer Center, Frankfurt, Germany;
- Moenig, Stefan Paul Hôpitaux Universitaires de Genève, Service de Chirurgie viscéral, Geneva, Switzerland;
- Vogel, Arndt Clinic of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany;
- Lorenzen, Sylvie Klinikum rechts der Isar der TU München, Munich, Germany;
- Homann, Nils MED. Klinik II, Klinikum Wolfsburg, Wolfsburg, Germany;
- Reissfelder, Christoph Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Dresden, Dresden, Germany;
- Bolling, Claus Agaplesion Markus Hospital, Frankfurt, Germany;
- Blau, Wolfgang Universitaetsklinikum Giessen, Giessen, Germany;
- Schmiegel, Wolff H. Ruhr-University Bochum, Bochum, Germany;
- Michl, Patrick Martin Luther University, Halle-Wittenberg, Halle, Germany;
- Caca, Karel Klinikum Ludwigsburg, Ludwigsburg, Germany;
- Schwarzbach, Matthias Klinikum Frankfurt-Höchst, Department of Surgery, Frankfurt, Germany;
- Hofheinz, Ralf University Medical Center Mannheim, Mannheim, Germany;
- Roedel, Claus Goethe University, Frankfurt, Germany;
- Shah, Manish A. New York-Presbyterian Hospital, New York, NY;
- Sasako, Mitsuru Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
- Bechstein, Wolf O. Department of General and Visceral Surgery, University Hospital Frankfurt, Frankfurt, Germany;
- Lang, Hauke University Medical Center of the Johannes Gutenberg University, General, Visceral and Transplant Surgery, Mainz, Germany;
- Pauligk, Claudia Institute of Clinical Cancer Research (IKF) at Krankenhaus Nordwest, UCT-University Cancer Center, Frankfurt, Germany;
- Al-Batran, Salah-Eddin Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany;
Published in:
- Journal of Clinical Oncology. - American Society of Clinical Oncology (ASCO). - 2017, vol. 35, no. 15_suppl, p. TPS4140-TPS4140
English
TPS4140 Background: Recent data indicates that surgical resection may bring a benefit for select patients with metastatic gastric / esophagogastric junction cancer. However, no data obtained in randomized trials is available up to now. The current RENAISSANCE trial investigates this long-lasting question about the role of surgical intervention in limited-metastatic gastric / esophagogastric junction cancer. Methods: This is a prospective, multicenter, randomized, investigator initiated phase III trial. In this study, previously untreated patients with limited metastatic stage (retroperitoneal lymph node metastases only or a maximum of one incurable organ site that is potentially resectable or locally controllable with or without retroperitoneal lymph nodes) will receive 4 cycles of FLOT (docetaxel 50 mg/m²; oxaliplatin 85 mg/m²; leucovorin 200 mg/m²; 5-FU 2,600 mg/m²), and if Her2+ with trastuzumab. Patients without disease progression after 4 cycles are randomized 1:1 to receive additional chemotherapy cycles or surgical resection of primary and metastases followed by subsequent chemotherapy. 271 patients are to be allocated to the trial, of which at least 176 patients will be randomized. The primary endpoint is overall survival; main secondary endpoints are quality of life parameters as assessed by EORTC-QLQ-C30 questionnaire, progression free survival and surgical morbidity and mortality. Recruitment has already started; currently (Feb 2017) 21 patients have been enrolled. EudraCT: 2014-002665-30. Clinical trial information: NCT02578368.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1200/jco.2017.35.15_suppl.tps4140
- ISSN 0732-183X
- Persistent URL
- https://sonar.ch/global/documents/144872
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