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Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals.

  • Martínez-Pacheco M Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Tenorio M Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Almonte L Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Fajardo V Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Godínez A Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Fernández D Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Cornejo-Páramo P Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Díaz-Barba K Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
  • Halbert J Center for Integrative Genomics, University of Lausanne, Switzerland.
  • Liechti A Center for Integrative Genomics, University of Lausanne, Switzerland.
  • Székely T Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom.
  • Urrutia AO Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom.
  • Cortez D Center for Genome Sciences, UNAM, Cuernavaca, Mexico.
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  • 2020-08-14
Published in:
  • Genome biology and evolution. - 2020
Y chromosome
dosage compensation mechanisms
gene expression levels
placental mammals
sex chromosomes
English Placental mammals present 180 million-year-old Y chromosomes that have retained a handful of dosage-sensitive genes. However, the expression evolution of Y-linked genes across placental groups has remained largely unexplored. Here, we expanded the number of Y gametolog sequences by analyzing ten additional species from previously unexplored groups. We detected seven remarkably conserved genes across 25 placental species with known Y repertoires. We then used RNA-seq data from 17 placental mammals to unveil the expression evolution of XY gametologs. We found that Y gametologs followed, on average, a 3-fold expression loss and that X gametologs also experienced some expression reduction, particularly in primates. Y gametologs gained testis specificity through an accelerated expression decay in somatic tissues. Moreover, despite the substantial expression decay of Y genes, the combined expression of XY gametologs in males is higher than that of both X gametologs in females. Finally, our work describes several features of the Y chromosome in the last common mammalian ancestor.
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  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/144963
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