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Thalamic reticular control of local sleep in mouse sensory cortex
Journal article

Thalamic reticular control of local sleep in mouse sensory cortex

  • Fernandez, Laura MJ ORCID Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
  • Vantomme, Gil ORCID Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
  • Osorio-Forero, Alejandro ORCID Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
  • Cardis, Romain Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
  • Béard, Elidie Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
  • Lüthi, Anita ORCID Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
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  • 2018-12-25
Published in:
  • eLife. - eLife Sciences Publications, Ltd. - 2018, vol. 7
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
General Medicine
English Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca2+ channel CaV3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a CaV3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when CaV3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/144978
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