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Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

  • Edefonti V Dipartimento di Scienze Cliche e di Comunità Sezione Di Statistica Medica E Biometria "Giulio A. Maccacaro,", Università degli Studi di Milano, Milan, Italy.
  • Hashibe M Division of Public Health, Department of Family and Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA.
  • Parpinel M Institute of Hygiene and Epidemiology, Department of Medical and Biological Sciences, University of Udine, Udine, Italy.
  • Turati F Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri,", Milan, Italy.
  • Serraino D Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy.
  • Matsuo K Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Kyushu, Japan.
  • Olshan AF Department of Epidemiology, Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
  • Zevallos JP Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Winn DM Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD.
  • Moysich K Department of Cancer Prevention and Control and Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY.
  • Zhang ZF Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA.
  • Morgenstern H Department of Epidemiology and Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Levi F Cancer Epidemiology Unit, Institute for Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland.
  • Kelsey K Department of Pathology and Laboratory Medicine and Department of Epidemiology, Brown University, Providence, RI.
  • McClean M Department of Environmental Health, Boston University School of Public Health, Boston, MA.
  • Bosetti C Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri,", Milan, Italy.
  • Galeone C Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri,", Milan, Italy.
  • Schantz S Department of Otolaryngology, New York Eye and Ear Infirmary, New York, NY.
  • Yu GP Medical Informatics Center, Peking University, Peking, China.
  • Boffetta P  Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY.
  • Amy Lee YC Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT.
  • Chuang SC Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
  • La Vecchia C Dipartimento di Scienze Cliche e di Comunità Sezione Di Statistica Medica E Biometria "Giulio A. Maccacaro,", Università degli Studi di Milano, Milan, Italy.
  • Decarli A Dipartimento di Scienze Cliche e di Comunità Sezione Di Statistica Medica E Biometria "Giulio A. Maccacaro,", Università degli Studi di Milano, Milan, Italy.
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  • 2015-01-29
Published in:
  • International journal of cancer. - 2015
INHANCE
head and neck cancer
laryngeal cancer
oral and pharyngeal cancer
vitamin C
Ascorbic Acid
Case-Control Studies
Head and Neck Neoplasms
Humans
International Agencies
Italy
Japan
Logistic Models
Risk Factors
Surveys and Questionnaires
Switzerland
United States
Vitamins
English Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend<0.001) and laryngeal cancers (OR = 0.52, 95% CI: 0.40-0.68, p for trend = 0.006), although in the presence of heterogeneity among studies for both sites. Inverse associations were consistently observed for the anatomical subsites of oral and pharyngeal cancer, and across strata of age, sex, education, body mass index, tobacco, and alcohol, for both cancer sites. The inverse association of vitamin C intake from foods with HNC may reflect a protective effect on these cancers; however, we cannot rule out other explanations.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/145272
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