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Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology.

  • Muraro A Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
  • Lemanske RF Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Castells M Drug Hypersensitivity and Desensitization Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Torres MJ Allergy Unit, Regional University Hospital of Malaga-IBIMA, UMA, Malaga, Spain.
  • Khan D Division of Allergy & Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Simon HU Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Bindslev-Jensen C Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.
  • Burks W Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
  • Poulsen LK Allergy Clinic, Copenhagen University Hospital at Gentofte Hospital, Copenhagen, Denmark.
  • Sampson HA Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Worm M Klinik für Dermatologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Nadeau KC Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
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  • 2017-01-26
Published in:
  • Allergy. - 2017
allergy
anaphylaxis
endotype
phenotype
precision medicine
Age of Onset
Allergens
Anaphylaxis
Biomarkers
Comorbidity
Drug Hypersensitivity
Food Hypersensitivity
Humans
Hypersensitivity
Phenotype
Precision Medicine
Severity of Illness Index
English This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy, and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology, which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease. Although significant progress has been made in defining endotypes for asthma, definitions of endotypes for food and drug allergy or for anaphylaxis lag behind. Progress has been made in discovery of biomarkers to guide a precision medicine approach to treatment of food and drug allergy, but further validation and quantification of these biomarkers are needed to allow their translation into practice in the clinical management of allergic disease.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/14530
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