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Complementary characteristics of homologous p-octiphenyl beta-barrels with ion channel and esterase activity.
Journal article

Complementary characteristics of homologous p-octiphenyl beta-barrels with ion channel and esterase activity.

  • Som A Department of Organic Chemistry, University of Geneva, CH-1211 Geneva 4, Switzerland.
  • Sakai N
  • Matile S
  • 2003-03-12
Published in:
  • Bioorganic & medicinal chemistry. - 2003
Algorithms
Dose-Response Relationship, Drug
Enzyme Inhibitors
Esterases
Ion Channel Gating
Ion Channels
Kinetics
Lipid Bilayers
Molecular Conformation
Oligopeptides
Protein Structure, Secondary
English We report that decreasing beta-sheet length in homologous multifunctional rigid-rod beta-barrels with internal histidines increases ion channel stability by three orders of magnitude, reduces binding activity by four orders of magnitude, and reduces esterase activity up to 22-times. These results are further used to evaluate methods employed to characterize suprastructure and activity of synthetic multifunctional pores formed by p-octiphenyl beta-barrels with emphasis on applicability of the Hille model to determine internal diameters and the Woodhull equation to locate internal active sites.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/145688
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