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A D-optimal design to model the performances of dressings and devices for negative pressure wound therapy.
Journal article

A D-optimal design to model the performances of dressings and devices for negative pressure wound therapy.

  • Salvo P Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124, Pisa, Italy. Electronic address: pietro.salvo@gmail.com.
  • Smajda R CSEM SA, Rue Jaquet-Droz 1, 2002 Neuchâtel, Switzerland.
  • Dini V Wound Healing Research Unit, Department of Dermatology, University of Pisa, Via Roma, 67, 56126 Pisa, Italy. Electronic address: valentinadini74@gmail.com.
  • Saxby C Smith & Nephew, Hessle Road 101, Hull, England, UK.
  • Voirin G CSEM SA, Rue Jaquet-Droz 1, 2002 Neuchâtel, Switzerland.
  • Romanelli M Wound Healing Research Unit, Department of Dermatology, University of Pisa, Via Roma, 67, 56126 Pisa, Italy. Electronic address: m.romanelli@med.unipi.it.
  • Di Francesco F Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124, Pisa, Italy. Electronic address: fabio.difrancesco@unipi.it.
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  • 2016-01-29
Published in:
  • Journal of tissue viability. - 2016
Chronic wounds
D-optimal design
Exudate transit time
Negative pressure wound therapy
Wound dressing
Bandages
Exudates and Transudates
Models, Theoretical
Negative-Pressure Wound Therapy
English A D-optimal design was used to identify and model variables that affect the transit time of wound exudate through an illustrative dressing used for negative pressure wound therapy. Many authors have addressed the clinical benefits of negative pressure wound therapy, but limited information is available on how to assess performances of dressings. In this paper, the transit time of wound exudate through a dressing was chosen as a model parameter to show how experimental design (DOE) can be used for this purpose. Results demonstrated that rate of exudate production, temperature and dressing thickness were the variables with the largest impact on transit time. The DOE approach could be used to model other dressing properties, like for example capability of absorbing excess exudate or breathability.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/145720
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