Journal article
Indications and limitations of bariatric intervention in severely obese children and adolescents with and without nonalcoholic steatohepatitis: ESPGHAN Hepatology Committee Position Statement.
- Nobili V *Unit of Hepato-Metabolic Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome †Department of Medicine and Surgery, Pediatric Section, University of Salerno, Baronissi (Salerno), Italy ‡First Department of Pediatrics, Semmelweis University, Semmelweis, Hungary §Department of Pediatrics, Karolinska University Hospital, CLINTEC, Karolinska Institutet, Stockholm, Sweden ||Paediatric Gastrointestinal, Liver and Nutrition Centre Variety Children's Hospital King's College Hospital NHS Foundation Trust Denmark Hill Camberwell, London, UK ¶Laboratory of Experimental and Molecular Hepatology, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University Graz, Graz, Austria #Pediatric Gastroenterology Unit, Children's Hospital, Place Amelie Raba, Bordeaux, France **Liver Unit, Birmingham Children's Hospital, Birmingham, UK ††Swiss Center for Liver Disease in Children, Pediatric Gastroenterology Unit, Department of Pediatrics, University Hospitals, Geneva, Switzerland ‡‡Department of Gastroenterology, Hepatology and Eating Disorders, Children's Memorial Health Institute, Warsaw, Poland §§Paediatric Viral Hepatitis, Paediatric Gastrointestinal, Liver and Nutrition Centre Variety Children's Hospital King's College Hospital NHS Foundation Trust Denmark Hill Camberwell, London, UK ||||Hannover Medical School, Children's Hospital, Division of Paediatric Gastroenterology and Hepatology, Hannover, Germany.
- Vajro P
- Dezsofi A
- Fischler B
- Hadzic N
- Jahnel J
- Lamireau T
- McKiernan P
- McLin V
- Socha P
- Tizzard S
- Baumann U
- 2015-01-16
Published in:
- Journal of pediatric gastroenterology and nutrition. - 2015
Adolescent
Adult
Bariatric Surgery
Child
Humans
Non-alcoholic Fatty Liver Disease
Obesity, Morbid
Weight Loss
English
Morbid obesity is strongly associated with nonalcoholic fatty liver disease (NAFLD), which is one of the most common causes of chronic liver disease worldwide. The present best treatment for NAFLD and nonalcoholic steatohepatitis (NASH) is weight reduction through lifestyle modification. Because of frustrating inefficiency of such a therapeutic approach, bariatric surgery is increasingly performed in adolescents as an alternative option for weight reduction. Standards of care and consensus for indications are, however, scarce. We explore the indications and limitations of bariatric surgery in children with severe obesity with and without NASH and aim to provide guidance for the exceptional indications for adolescents with extreme obesity with major comorbidity that may benefit from these controversial interventions. Present evidence suggests that bariatric surgery can decrease the grade of steatosis, hepatic inflammation, and fibrosis in NASH. Uncomplicated NAFLD is not an indication for bariatric surgery. Roux-en-Y gastric bypass is considered a safe and effective option for adolescents with extreme obesity, as long as an appropriate long-term follow-up is provided. Laparoscopic adjustable gastric banding has not been approved by the Food and Drug Administration for use in adolescents and therefore should be considered investigational. Finally, sleeve gastrectomy and other types of weight loss surgery that have grown increasingly common in adults, still need to be considered investigational. Temporary devices may be increasingly being used in pediatrics; however, future studies, including a long-term risk analysis of patients who undergo surgery, are much needed to clarify the exact indications for bariatric surgery in adolescents.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1097/MPG.0000000000000715
- PMID 25591123
- Persistent URL
- https://sonar.ch/global/documents/147739
Statistics
Document views: 20
File downloads: