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Genomics of host-pathogen interactions.
Journal article

Genomics of host-pathogen interactions.

  • Rausell A Institute of Microbiology, University Hospital, University of Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Telenti A Institute of Microbiology, University Hospital, University of Lausanne, Switzerland. Electronic address: amalio.telenti@chuv.ch.
  • 2014-06-28
Published in:
  • Current opinion in immunology. - 2014
Animals
Chromosome Mapping
Evolution, Molecular
Genomics
Host-Pathogen Interactions
Humans
English The study of immunity against infection can be framed in the context of genomics. First, long-term association with pathogens results in genomic signatures that result from positive selection. Evolutionary pressures tailor species or individual responses to pathogens, that may be associated with skewed patterns of immunity. Second, recent human population expansion carries an increasing burden of genetic mutation that can result in sporadic immunodeficiencies, and more generally, in diversity in susceptibility to infection. This review highlights current concepts and tools for the analysis of genomes and stresses the interest of these approaches in immunity.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/148105
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