Journal article
Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease.
- Hock CH Department of Psychiatry Research, University of Zürich, Switzerland.
- Heese K
- Olivieri G
- Hulette CH
- Rosenberg C
- Nitsch RM
- Otten U
- 2000-08-29
Published in:
- Journal of neural transmission. Supplementum. - 2000
Alzheimer Disease
Cerebral Cortex
Hippocampus
Humans
Nerve Growth Factors
Parietal Lobe
Receptor, trkA
Receptors, Nerve Growth Factor
English
We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Measurement of CSF levels of NGF may add to the repertoire of potential biochemical diagnostic markers in living AD patients.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1007/978-3-7091-6781-6_19
- PMID 10961429
- Persistent URL
- https://sonar.ch/global/documents/148154
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