Journal article
Reference values of fetal peak systolic blood flow velocity in the middle cerebral artery at 19-40 weeks of gestation.
- Kurmanavicius J Perinatal Research Unit, Department of Obstetrics, Zurich University Hospital, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.
- Streicher A
- Wright EM
- Wisser J
- Müller R
- Royston P
- Huch R
- Huch A
- Zimmermann R
- 2001-03-14
Published in:
- Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. - 2001
Blood Flow Velocity
Female
Fetus
Gestational Age
Humans
Linear Models
Middle Cerebral Artery
Pregnancy
Prospective Studies
Reference Values
Ultrasonography, Doppler, Color
Ultrasonography, Prenatal
English
OBJECTIVES
The objectives of this prospective study were (i) to establish new reference values of peak systolic blood flow velocity measurement in the fetal middle cerebral artery (MCA-PSV) following validated methodological guidelines and (ii) to develop a method to calculate Z-scores of MCA-PSV.
PATIENTS AND METHODS
Cross-sectional data were obtained from 331 pregnant women between 19 and 40 weeks' gestation. Reference ranges for MCA-PSV were constructed and for each measurement linear regression models were fitted separately to the mean and standard deviations (SD) as a function of gestational age. An application to calculate Z-scores was developed. A comparison was made between the reference ranges produced in our study and those of a previous one.
RESULTS
A new chart, table of centiles and regression equations of MCA-PSV are presented. Comparison of our reference ranges with ones produced in a previous study showed similar 5th centile values. However, the values for the 50th and 95th centiles between 19 and 28 gestational weeks were lower in our study.
CONCLUSIONS
We have constructed reference ranges for MCA-PSV which, because they are derived from a larger number of examinations in the 15-20-week period and because the methodological flaws of the previously published study have been eliminated, we consider to be more accurate and therefore more useful for clinical practice.
The objectives of this prospective study were (i) to establish new reference values of peak systolic blood flow velocity measurement in the fetal middle cerebral artery (MCA-PSV) following validated methodological guidelines and (ii) to develop a method to calculate Z-scores of MCA-PSV.
PATIENTS AND METHODS
Cross-sectional data were obtained from 331 pregnant women between 19 and 40 weeks' gestation. Reference ranges for MCA-PSV were constructed and for each measurement linear regression models were fitted separately to the mean and standard deviations (SD) as a function of gestational age. An application to calculate Z-scores was developed. A comparison was made between the reference ranges produced in our study and those of a previous one.
RESULTS
A new chart, table of centiles and regression equations of MCA-PSV are presented. Comparison of our reference ranges with ones produced in a previous study showed similar 5th centile values. However, the values for the 50th and 95th centiles between 19 and 28 gestational weeks were lower in our study.
CONCLUSIONS
We have constructed reference ranges for MCA-PSV which, because they are derived from a larger number of examinations in the 15-20-week period and because the methodological flaws of the previously published study have been eliminated, we consider to be more accurate and therefore more useful for clinical practice.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1046/j.1469-0705.2001.00311.x
- PMID 11244656
- Persistent URL
- https://sonar.ch/global/documents/148202
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