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DNA repair: bioinformatics helps reverse methylation damage.
Journal article

DNA repair: bioinformatics helps reverse methylation damage.

  • Jiricny J Institute of Medical Radiobiology of the University of Zürich and the Paul Scherrer Institute, August Forel-Strasse 7, CH-8008 Zürich, Switzerland. jiricny@imr.unizh.ch
  • 2002-12-25
Published in:
  • Current biology : CB. - 2002
Adenine
Computational Biology
Cytosine
DNA Methylation
DNA Repair
Escherichia coli
Escherichia coli Proteins
Mixed Function Oxygenases
English Recent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, which oxidises the methyl groups of 1-methyladenine and 3-methylcytosine to hydroxymethyl moieties; the oxidised groups are subsequently released as formaldehyde, regenerating the unmodified bases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/148340
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