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Sleeping Sickness in the 'Omics Era.
Journal article

Sleeping Sickness in the 'Omics Era.

  • Tiberti N Translational Biomarker Group, University of Geneva, Geneva, Switzerland.
  • Sanchez JC Translational Biomarker Group, University of Geneva, Geneva, Switzerland.
  • 2018-03-09
Published in:
  • Proteomics. Clinical applications. - 2018
Biomarkers
Parasite biology
Sleeping sickness
Trypanosoma brucei
‘Omics
Animals
Communicable Disease Control
Genomics
Humans
Metabolomics
Neglected Diseases
Proteomics
Tropical Medicine
Trypanocidal Agents
Trypanosoma brucei brucei
Trypanosomiasis, African
English Sleeping sickness is a neglected tropical disease caused by Trypanosoma brucei parasites, affecting the poorest communities in sub-Saharan Africa. The great efforts done by the scientific community, local governments, and non-governmental organizations (NGOs) via active patients' screening, vector control, and introduction of improved treatment regimens have significantly contributed to the reduction of human African trypanosomiasis (HAT) incidence during the last 15 years. Consequently, the WHO has announced the objective of HAT elimination as a public health problem by 2020. Studies at both parasite and host levels have improved our understanding of the parasite biology and the mechanisms of parasite interaction with its mammalian host. In this review, the impact that 'omics studies have had on sleeping sickness by revealing novel properties of parasite's subcellular organelles are summarized, by highlighting changes induced in the host during the infection and by proposing potential disease markers and therapeutic targets.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/149021
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