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Regulation and function of interleukin-36 cytokines.
Journal article

Regulation and function of interleukin-36 cytokines.

  • Bassoy EY Division of Rheumatology, Department of Internal Medicine Specialties & Department of Pathology-Immunology, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
  • Towne JE Immunology Discovery, Janssen Research and Development, San Diego, CA, USA.
  • Gabay C Division of Rheumatology, Department of Internal Medicine Specialties & Department of Pathology-Immunology, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
  • 2017-12-17
Published in:
  • Immunological reviews. - 2018
IL-1 family
inflammation
intestine
lung
psoriasis
Animals
Arthritis, Psoriatic
Epithelial Cells
Fibroblasts
Humans
Inflammation
Interleukin-1
Interleukin-1 Receptor Accessory Protein
Intestines
Protein Binding
Receptors, Interleukin
Skin
English The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a common receptor composed of IL-36R and IL-1RAcP to stimulate inflammatory responses. IL-36Ra is a natural antagonist that binds to IL-36R, but does not recruit the co-receptor IL-1RAcP and does not stimulate any intracellular responses. The IL-36 cytokines are expressed predominantly by epithelial cells and act on a number of cells including immune cells, epithelial cells, and fibroblasts. Processing of the N-terminus is required for full agonist or antagonist activity for all IL-36 members. The role of IL-36 has been extensively demonstrated in the skin where it can act on keratinocytes and immune cells to induce a robust inflammatory response that has been implicated in psoriatic disorders. Emerging data also suggest a role for this cytokine family in pulmonary and intestinal physiology and pathology.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/149507
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