Journal article
Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project.
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Horvatovich P
Analytical Biochemistry, Department of Pharmacy, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
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Lundberg EK
Science for Life Laboratory, KTH - Royal Institute of Technology , SE-171 21 Stockholm, Sweden.
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Chen YJ
Institute of Chemistry, Academia Sinica , 128 Academia Road Sec. 2, Taipei 115, Taiwan.
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Sung TY
Institute of Information Science, Academia Sinica , 128 Academia Road Sec. 2, Taipei 115, Taiwan.
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He F
The State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , No. 27 Taiping Road, Haidian District, Beijing 100850, China.
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Nice EC
Department of Biochemistry and Molecular Biology, Monash University , Clayton, Victoria 3800, Australia.
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Goode RJ
Department of Biochemistry and Molecular Biology, Monash University , Clayton, Victoria 3800, Australia.
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Yu S
Department of Biochemistry and Molecular Biology, Monash University , Clayton, Victoria 3800, Australia.
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Ranganathan S
Department of Chemistry and Biomolecular Sciences and ARC Centre of Excellence in Bioinformatics, Macquarie University , Sydney, New South Wales 2109, Australia.
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Baker MS
Australian School of Advanced Medicine, Macquarie University , Sydney, NSW 2109, Australia.
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Domont GB
Proteomics Unit, Institute of Chemistry, Federal University of Rio de Janeiro , Cidade Universitária, Av Athos da Silveira Ramos 149, CT-A542, 21941-909 Rio de Janeriro, Rj, Brazil.
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Velasquez E
Proteomics Unit, Institute of Chemistry, Federal University of Rio de Janeiro , Cidade Universitária, Av Athos da Silveira Ramos 149, CT-A542, 21941-909 Rio de Janeriro, Rj, Brazil.
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Li D
The State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , No. 27 Taiping Road, Haidian District, Beijing 100850, China.
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Liu S
Beijing Institute of Genomics and BGI Shenzhen , No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China.
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Wang Q
Beijing Institute of Genomics and BGI Shenzhen , No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China.
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He QY
■ Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University , Guangzhou 510632, China.
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Menon R
Department of Computational Medicine & Bioinformatics, University of Michigan , 100 Washtenaw Avenue, Ann Arbor, Michigan 48109-2218, United States.
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Guan Y
Departments of Computational Medicine & Bioinformatics and Computer Sciences, University of Michigan , 100 Washtenaw Avenue, Ann Arbor, Michigan 48109-2218, United States.
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Corrales FJ
ProteoRed-ISCIII, Biomolecular and Bioinformatics Resources Platform (PRB2), Spanish Consortium of C-HPP (Chr-16), CIMA, University of Navarra, 31008 Pamplona, Spain.
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Segura V
ProteoRed-ISCIII, Biomolecular and Bioinformatics Resources Platform (PRB2), Spanish Consortium of C-HPP (Chr-16), CIMA, University of Navarra, 31008 Pamplona, Spain.
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Casal JI
Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CIB-CSIC) , 28040 Madrid, Spain.
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Pascual-Montano A
Centro Nacional de Biotecnologia (CNB-CSIC) , Cantoblanco, 28049 Madrid, Spain.
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Albar JP
Centro Nacional de Biotecnologia (CNB-CSIC) , Cantoblanco, 28049 Madrid, Spain.
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Fuentes M
Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
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Gonzalez-Gonzalez M
Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
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Diez P
Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
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Ibarrola N
Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
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Degano RM
Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
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Mohammed Y
University of Victoria -Genome British Columbia Proteomics Centre, Vancouver Island Technology Park, #3101-4464 Markham Street, Victoria, British Columbia V8Z 7X8, Canada.
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Borchers CH
University of Victoria -Genome British Columbia Proteomics Centre, Vancouver Island Technology Park, #3101-4464 Markham Street, Victoria, British Columbia V8Z 7X8, Canada.
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Urbani A
Proteomics and Metabonomic, Laboratory, Fondazione Santa Lucia , Rome, Italy.
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Soggiu A
Department of Veterinary Science and Public Health (DIVET), University of Milano , via Celoria 10, 20133 Milano, Italy.
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Yamamoto T
Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University , Niigata, Japan.
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Salekdeh GH
Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
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Archakov A
Orechovich Institute of Biomedical Chemistry , Moscow, Russia.
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Ponomarenko E
Orechovich Institute of Biomedical Chemistry , Moscow, Russia.
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Lisitsa A
Orechovich Institute of Biomedical Chemistry , Moscow, Russia.
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Lichti CF
Department of Pharmacology and Toxicology, The University of Texas Medical Branch , Galveston, Texas 77555-0617, United States.
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Mostovenko E
Department of Pharmacology and Toxicology, The University of Texas Medical Branch , Galveston, Texas 77555-0617, United States.
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Kroes RA
Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University , 1801 Maple Ave., Suite 4300, Evanston, Illinois 60201, United States.
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Rezeli M
Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University , BMC D13, 221 84 Lund, Sweden.
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Végvári Á
Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University , BMC D13, 221 84 Lund, Sweden.
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Fehniger TE
Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University , BMC D13, 221 84 Lund, Sweden.
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Bischoff R
Analytical Biochemistry, Department of Pharmacy, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
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Vizcaíno JA
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, CB10 1SD, Hinxton, Cambridge, United Kingdom.
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Deutsch EW
Institute for Systems Biology , 401 Terry Avenue North, Seattle, Washington 98109, United States.
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Lane L
SIB Swiss Institute of Bioinformatics , Geneva, Switzerland.
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Nilsson CL
Department of Pharmacology and Toxicology, The University of Texas Medical Branch , Galveston, Texas 77555-0617, United States.
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Marko-Varga G
Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University , BMC D13, 221 84 Lund, Sweden.
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Omenn GS
Departments of Computational Medicine & Bioinformatics, Internal Medicine, Human Genetics and School of Public Health, University of Michigan , 100 Washtenaw Avenue, Ann Arbor, Michigan 48109-2218, United States.
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Jeong SK
Departments of Integrated Omics for Biomedical Science & Biochemistry, College of Life Science and Technology, Yonsei Proteome Research Center, Yonsei University , Seoul, 120-749, Korea.
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Lim JS
Departments of Integrated Omics for Biomedical Science & Biochemistry, College of Life Science and Technology, Yonsei Proteome Research Center, Yonsei University , Seoul, 120-749, Korea.
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Paik YK
Departments of Integrated Omics for Biomedical Science & Biochemistry, College of Life Science and Technology, Yonsei Proteome Research Center, Yonsei University , Seoul, 120-749, Korea.
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Hancock WS
The Barnett Institute of Chemical and Biological Analysis, Northeastern University , 140 The Fenway, Boston, Massachusetts 02115, United States.
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Published in:
- Journal of proteome research. - 2015
English
This paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed "missing proteins") in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification. The C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms the basis of the C-HPP's activities; therefore, we have summarized some of the key approaches and their roles in the project. We present new analytical technologies that improve the chemical space and lower detection limits coupled to bioinformatics tools and some publicly available resources that can be used to improve data analysis or support the development of analytical assays. Most of this paper's content has been compiled from posters, slides, and discussions presented in the series of C-HPP workshops held during 2014. All data (posters, presentations) used are available at the C-HPP Wiki (http://c-hpp.webhosting.rug.nl/) and in the Supporting Information.
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Language
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Open access status
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green
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/149536
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