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Statin-induced autoimmune necrotizing myopathy with pharyngeal muscles involvement.
Journal article

Statin-induced autoimmune necrotizing myopathy with pharyngeal muscles involvement.

  • Mirlesse N Department of Internal Medicine of the Aged, Trois-Chêne Geneva University Hospital, Geneva, Switzerland.
  • Egervari K Service of Clinical Pathology, Department of Genetic Medicine, Laboratory and Pathology, Geneva University Hospital, Geneva, Switzerland.
  • Bornand A Service of Clinical Pathology, Department of Genetic Medicine, Laboratory and Pathology, Geneva University Hospital, Geneva, Switzerland.
  • Lecluse J Department of Internal Medicine of the Aged, Trois-Chêne Geneva University Hospital, Geneva, Switzerland.
  • Lobrinus JA Service of Clinical Pathology, Department of Genetic Medicine, Laboratory and Pathology, Geneva University Hospital, Geneva, Switzerland.
  • Scheffler M Department of Radiology, Geneva University Hospital, Geneva, Switzerland.
  • Serratrice C Department of Internal Medicine of the Aged, Trois-Chêne Geneva University Hospital, Geneva, Switzerland.
  • Prendki V Department of Internal Medicine of the Aged, Trois-Chêne Geneva University Hospital, Geneva, Switzerland.
  • Cuvelier C Department of Internal Medicine of the Aged, Trois-Chêne Geneva University Hospital, Geneva, Switzerland.
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  • 2020-03-10
Published in:
  • Age and ageing. - 2020
anti-HMGCR necrotising myopathy
dysphagia
older patients
pharyngeal muscles necrosis
statins
English Statins are widely prescribed in the treatment of hypercholesterolemia. While their efficacy in the secondary prevention of vascular events is proven, their safety profile in older patients with multiple co-morbidities and polypharmacy remains questionable. Although rare, antihydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy is a severe adverse effect of statins, manifesting as myalgias, proximal muscle weakness, muscle cell necrosis and rhabdomyolysis. We report an uncommon case of an autopsy-proven anti-HMGCR necrotising myopathy predominately affecting pharyngeal muscles in an older patient, leading to dysphagia, pneumonia and death within 3 weeks from onset. Clinicians should screen for dysphagia in any patient with suspected anti-HMGCR myopathy, order an anti-HMGCR antibody titre and consider prompt immunosupressive therapy.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/149706
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