Targeting Antibiotic Tolerance, Pathogen by Pathogen.
- Meylan S Department of Biomedicine, Basel University Hospital, Basel, CH-4031, Switzerland; Division of Infectious Diseases and Hospital Epidemiology, Basel University Hospital, Basel, CH-4031, Switzerland; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
- Andrews IW Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
- Collins JJ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address: jimjc@mit.edu.
- 2018-03-10
Published in:
- Cell. - 2018
Animals
Anti-Bacterial Agents
Bacteria
Bacterial Infections
Bacterial Physiological Phenomena
Biofilms
Drug Tolerance
Host-Pathogen Interactions
Humans
Species Specificity
English
Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathogen approach to illustrate the clinical significance of antibiotic tolerance and discuss how the physiology of specific pathogens in their infection environments impacts the mechanistic underpinnings of tolerance. We describe how these insights are leading to the development of species-specific therapeutic strategies for targeting antibiotic tolerance and highlight experimental platforms that are enabling us to better understand the complexities of drug-tolerant pathogens in in vivo settings.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.cell.2018.01.037
- PMID 29522744
- Persistent URL
- https://sonar.ch/global/documents/150005
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