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TRIM-NHL proteins in development and disease.
Journal article

TRIM-NHL proteins in development and disease.

  • Tocchini C Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
  • Ciosk R Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. Electronic address: rafal.ciosk@fmi.ch.
  • 2015-10-31
Published in:
  • Seminars in cell & developmental biology. - 2015
Bardet-Biedl syndrome
Brat
LIN-41
Limb girdle muscular dystrophy 2H
Mei-P26
NHL
Sarcotubular myopathy
TRIM
TRIM32
TRIM71
Animals
Carrier Proteins
Genetic Predisposition to Disease
Humans
Morphogenesis
Mutation
Nuclear Proteins
Phylogeny
Transcription Factors
Tripartite Motif Proteins
Ubiquitin-Protein Ligases
English TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for therapeutic intervention. The purpose of this review is to provide a systematic and comprehensive summary on the most studied TRIM-NHL proteins, highlighting examples where connections were established between structural features, molecular functions and biological outcomes.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/150120
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