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Journal article

Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.

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  • 2004-01-14
Published in:
  • The Journal of experimental medicine. - 2004
Animals
B-Lymphocytes
Cell Differentiation
Cell Division
Chimera
Cytoskeletal Proteins
Female
Hematopoiesis
Integrases
Lymphopoiesis
Mice
Mice, Inbred C57BL
Mice, Knockout
Phenotype
Proto-Oncogene Proteins
Signal Transduction
T-Lymphocytes
Trans-Activators
Wnt Proteins
beta Catenin
English Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/150540
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