Osmolarity: A hidden factor in Nanotoxicology.

Moayyedi S; Mashinchian O; Dinarvand R

doi:10.1186/s40199-016-0146-9

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Journal article

Osmolarity: A hidden factor in Nanotoxicology.

Moayyedi S Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran.
Mashinchian O Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Tehran University of Medical Sciences, Lausanne, Switzerland.
Dinarvand R Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. dinarvand@tums.ac.ir.

2016-03-23

Published in:

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. - 2016

English In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of long circulating nanocarriers in the blood stream on osmolarity of plasma has not been reported before. In this study, osmotic pressure developed by some commercially available nanocarriers was estimated based on Van't Hoff equation. It is noteworthy that theoretically, nanocarriers do not have any significant effect on osmolarity of plasma. However, it is worth being evaluated experimentally in order to be taken into account in future studies.

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