On the unfounded enthusiasm for soft selective sweeps.
- Jensen JD 1] School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1007, Switzerland [2] Swiss Institute of Bioinformatics (SIB), Lausanne 1007, Switzerland.
- 2014-10-28
Published in:
- Nature communications. - 2014
Adaptation, Physiological
Animals
Biological Evolution
Drosophila melanogaster
Genetic Variation
Humans
Models, Biological
Selection, Genetic
English
Underlying any understanding of the mode, tempo and relative importance of the adaptive process in the evolution of natural populations is the notion of whether adaptation is mutation limited. Two very different population genetic models have recently been proposed in which the rate of adaptation is not strongly limited by the rate at which newly arising beneficial mutations enter the population. However, empirical and experimental evidence to date challenges the recent enthusiasm for invoking these models to explain observed patterns of variation in humans and Drosophila.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1038/ncomms6281
- PMID 25345443
- Persistent URL
- https://sonar.ch/global/documents/150962
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