Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models.
- Vianello S Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address: stefano.vianello@epfl.ch.
- Lutolf MP Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Institute of Chemical Sciences and Engineering, School of Basic Science (SB), EPFL, Lausanne, Switzerland. Electronic address: matthias.lutolf@epfl.ch.
- 2019-03-27
Published in:
- Developmental cell. - 2019
bioengineering
early mammalian development
gastruloids
in vitro culture
mechanics
organoids
Animals
Bioengineering
Biophysics
Embryo, Mammalian
Embryonic Development
Humans
Mammals
Models, Biological
English
Research in developmental biology has been recently enriched by a multitude of in vitro models recapitulating key milestones of mammalian embryogenesis. These models obviate the challenge posed by the inaccessibility of implanted embryos, multiply experimental opportunities, and favor approaches traditionally associated with organoids and tissue engineering. Here, we provide a perspective on how these models can be applied to study the mechano-geometrical contributions to early mammalian development, which still escape direct verification in species that develop in utero. We thus outline new avenues for robust and scalable perturbation of geometry and mechanics in ways traditionally limited to non-implanting developmental models.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.devcel.2019.02.024
- PMID 30913407
- Persistent URL
- https://sonar.ch/global/documents/151314
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