Structure and biology of self lipid antigens.

De Libero G; Mori L

doi:10.1007/978-3-540-69511-0_3

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Journal article

Structure and biology of self lipid antigens.

De Libero G Department of Research, University Hospital, Basel, Switzerland. gennaro.delibero@unibas.ch
Mori L

2007-06-28

Published in:

Current topics in microbiology and immunology. - 2007

English Self lipid antigens induce selection and expansion of autoreactive T cells which have a role in immunoregulation and disease pathogenesis. Here we review the important biological rules which determine lipid immunogenicity. The impact of lipid structure, synthesis, traffic, membrane distribution and CD1 loading are discussed.

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