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Recognition of lipid antigens by T cells.
Journal article

Recognition of lipid antigens by T cells.

  • De Libero G Experimental Immunology, Department of Research, University Hospital, Basel 4031, Switzerland. gennaro.delibero@unibas.ch
  • Mori L
  • 2005-06-02
Published in:
  • Nature reviews. Immunology. - 2005
Animals
Antigen-Presenting Cells
Antigens, Bacterial
Antigens, CD1
Autoantigens
Autoimmunity
Biological Transport
Humans
Immunologic Memory
Lipid Metabolism
Lipids
Lymphopoiesis
T-Lymphocytes
English Recent studies have shown that the recognition of lipid antigens by the immune system is important for defence against infection and other diseases, and that lipid-specific responses occur at higher frequencies than previously suspected. Thanks to several recent advances in this field, we now have a better appreciation of the molecular and cellular requirements of T-cell stimulation by lipids. These findings have raised new questions about the mechanisms of lipid presentation, the priming and clonal expansion of lipid-specific T cells, and their differentiation into memory cells. A greater understanding of lipid-specific T cells and the molecular mechanisms of lipid immunogenicity should facilitate the development of lipid-based vaccines.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/15185
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