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A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children.
Journal article

A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children.

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  • 1996-11-01
Published in:
  • The American journal of tropical medicine and hygiene. - 1996
Adolescent
Adult
Albendazole
Ancylostomatoidea
Animals
Anthelmintics
Ascaris lumbricoides
Child
Female
Follow-Up Studies
Helminthiasis
Humans
Ivermectin
Male
Strongyloides stercoralis
Strongyloidiasis
Tanzania
Trichuris
English A randomized trial carried out in rural Zanzibar comparing a single dose of 200 micrograms/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with Strongyloides stercoralis infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against Ascaris lumbricoides, Trichuris trichiura was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and a highly effective single dose treatment for S. stercoralis and A. lumbricoides, while it is not an alternative for the treatment of T. trichiura and hookworm infections.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/15210
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