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Inactivated virosome hepatitis A vaccine.
Journal article

Inactivated virosome hepatitis A vaccine.

  • 1994-02-05
Published in:
  • Lancet (London, England). - 1994
Adjuvants, Immunologic
Adult
Antibodies, Viral
Drug Carriers
Enzyme-Linked Immunosorbent Assay
Female
Hepatitis A
Hepatitis A Virus, Human
Humans
Immunization, Secondary
Influenza A virus
Male
Vaccines, Inactivated
Vaccines, Synthetic
Viral Hepatitis Vaccines
Virion
English Immunopotentiating reconstituted influenza virosomes (IRIV) are efficient carrier systems for small virion particles such as hepatitis A virus (HAV). We evaluated immunogenicity and tolerability of an IRIV-HAV vaccine and the effectiveness of a booster by immunising 104 healthy HAV seronegative volunteers. A single dose was highly immunogenic, since 98% of volunteers had seroconverted after 2 weeks. Anti-HAV titres remained high, with 100% seroconversion rate 1 year later, when the booster was given. The vaccine was effective, with a 22-fold increase in geometric mean titres 1 month later. No serious adverse reactions were observed.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/152367
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