Interleukin-17 in Antifungal Immunity.
- Sparber F Section of Immunology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 266a, CH-8057 Zürich, Switzerland. florian.sparber@uzh.ch.
- LeibundGut-Landmann S Section of Immunology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 266a, CH-8057 Zürich, Switzerland. salome.leibundgut-landmann@uzh.ch.
- 2019-04-25
Published in:
- Pathogens (Basel, Switzerland). - 2019
English
The field of IL-17 biology has received much attention over the last decade owing to the pathogenic role of this cytokine in psoriasis and other autoinflammatory disorders and the successful implementation of IL-17-targeting therapies in patients suffering from these diseases. IL-17-mediated pathologies are contrasted by the important host beneficial effects of this cytokine. IL-17 is essential for regulating microbial colonization in barrier tissues. Rare congenital defects in the IL-17 pathway exemplify the relevance of IL-17 in protective immunity against the opportunistic fungal pathogen C. albicans. However, more recently, evidence is accumulating that IL-17 can also provide protection against fungi other than C. albicans. Importantly, protective IL-17 responses directed against commensal fungi can, under certain conditions, promote inflammation with detrimental consequences for the host, thereby assigning fungi a new role as disease-promoting factors apart from their role as potential infectious agents.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3390/pathogens8020054
- PMID 31013616
- Persistent URL
- https://sonar.ch/global/documents/152399
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