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Intracellular stability of nonreplicating paramyxovirus nucleocapsids.
Journal article

Intracellular stability of nonreplicating paramyxovirus nucleocapsids.

  • 1990-05-01
Published in:
  • Virology. - 1990
Animals
Capsid
Cells, Cultured
Cricetinae
Measles
Measles virus
Parainfluenza Virus 1, Human
Paramyxoviridae
RNA, Viral
Ultraviolet Rays
Vaccination
Viral Core Proteins
Virus Replication
English Using Northern blot analysis, we have demonstrated the ability of infectious measles and Sendai virus particles to rescue the intracellular replication of their homologous defective interfering (DI) nucleocapsids up to 3 days and 1 day, respectively, after initial DI infection. The half-life of the paramyxovirus DI nucleocapsids was therefore judged to be similar to that of rhabdoviruses, and to significantly differ from that of orthomyxoviruses. Moreover, we conclude that the intracellular half-life of measles virus DI nucleocapsids makes possible DI replication in the human body after vaccination with a DI-contaminated attenuated live virus, even when this vaccination represents a low multiplicity of infection.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/152541
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