Hypothermic machine perfusion in liver transplantation.
- Karangwa S Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Surgery, Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- Panayotova G Department of Surgery, Division of Transplant and HPB Surgery, Rutgers NJMS/ University Hospital, Newark, NJ, USA.
- Dutkowski P Department of Surgery & Transplantation, University Hospital Zurich, Switzerland.
- Porte RJ Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Surgery, Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- Guarrera JV Department of Surgery, Division of Transplant and HPB Surgery, Rutgers NJMS/ University Hospital, Newark, NJ, USA.
- Schlegel A The Liver Unit, Queen Elizabeth University Hospital Birmingham, United Kingdom. Electronic address: Andrea.Schlegel@uhb.nhs.uk.
- 2020-05-01
Published in:
- International journal of surgery (London, England). - 2020
English
Dynamic preservation strategies are a promising option to improve graft quality before transplantation, and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which intends to mimic physiological conditions in the human body, with subsequent clinical application for up to 24 hrs, hypothermic perfusion is mainly used for a relatively short period with protection of mitochondria and subsequent reduction of oxidative injury upon implantation. The results from two randomized controlled trials, where recruitment has finished are expected this year. Both ex situ perfusion techniques are increasingly applied in clinical transplantation including recent reports on viability assessment, which could open the door for an increased liver utilization in the future.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.ijsu.2020.04.057
- PMID 32353556
- Persistent URL
- https://sonar.ch/global/documents/152739
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