Journal article
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women
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Trakoshis, Stavros
Department of Psychology, University of Cyprus, Nicosia, Cyprus
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Martínez-Cañada, Pablo
Optical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy
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Rocchi, Federico
Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy
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Canella, Carola
Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy
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You, Wonsang
Artificial Intelligence and Image Processing Laboratory, Department of Information and Communications Engineering, Sun Moon University, Asan, Republic of Korea
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Chakrabarti, Bhismadev
Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom
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Ruigrok, Amber NV
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
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Bullmore, Edward T
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
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Suckling, John
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
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Markicevic, Marija
Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland
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Zerbi, Valerio
ORCID
Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland
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Baron-Cohen, Simon
Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, United Kingdom
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Gozzi, Alessandro
ORCID
Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy
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Lai, Meng-Chuan
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
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Panzeri, Stefano
ORCID
Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy
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Lombardo, Michael V
ORCID
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
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Published in:
- eLife. - eLife Sciences Publications, Ltd. - 2020, vol. 9
English
Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling and in-vivo chemogenetic manipulations in mice, we first show that a time-series metric estimated from fMRI BOLD signal, the Hurst exponent (H), can be an index for underlying change in the synaptic E:I ratio. In autism we find that H is reduced, indicating increased excitation, in the medial prefrontal cortex (MPFC) of autistic males but not females. Increasingly intact MPFC H is also associated with heightened ability to behaviorally camouflage social-communicative difficulties, but only in autistic females. This work suggests that H in BOLD can index synaptic E:I ratio and that E:I imbalance affects autistic males and females differently.
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Language
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Open access status
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gold
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/153214
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