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Targeting bacterial toxins.
Journal article

Targeting bacterial toxins.

  • Ivarsson ME Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Wolfgang-Pauli-Strasse 10, Zurich, Switzerland.
  • Leroux JC
  • Castagner B
  • 2012-03-24
Published in:
  • Angewandte Chemie (International ed. in English). - 2012
Antigens, Bacterial
Bacillus anthracis
Bacterial Toxins
Cholera Toxin
Clostridium difficile
Humans
Molecular Targeted Therapy
Shiga Toxin
Vibrio cholerae
English Protein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxin-mediated pathogenicity. Despite recent and significant advances in the field, a rationally designed drug that targets toxins has yet to reach the market. This Review presents the state of the art in bacterial toxin targeted drug development with a critical consideration of achieved breakthroughs and withstanding challenges. The discussion focuses on A-B-type protein toxins secreted by four species of bacteria, namely Clostridium difficile (toxins A and B), Vibrio cholerae (cholera toxin), enterohemorrhagic Escherichia coli (Shiga toxin), and Bacillus anthracis (anthrax toxin), which are the causative agents of diseases for which treatments need to be improved.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/153323
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