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Aggregate dermal exposure to cyclic siloxanes in personal care products: implications for risk assessment.
Journal article

Aggregate dermal exposure to cyclic siloxanes in personal care products: implications for risk assessment.

  • Biesterbos JW Radboud university medical center, Department for Health Evidence, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Jacqueline.Biesterbos@radboudumc.nl.
  • Beckmann G Radboud university medical center, Department for Health Evidence, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Gwendolyn.Beckmann@radboudumc.nl.
  • van Wel L Radboud university medical center, Department for Health Evidence, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Luuk.vanWel@radboudumc.nl.
  • Anzion RB Radboud university medical center, Department for Health Evidence, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Rob.Anzion@radboudumc.nl.
  • von Goetz N Swiss Federal Institute of Technology Zürich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. Electronic address: Natalie.von.goetz@chem.ethz.ch.
  • Dudzina T Swiss Federal Institute of Technology Zürich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. Electronic address: tatsiana.dudzina@chem.ethz.ch.
  • Roeleveld N Radboud university medical center, Department for Health Evidence, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Radboud university medical center, Department of Pediatrics, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Nel.Roeleveld@radboudumc.nl.
  • Ragas AM Radboud University Nijmegen, Department of Environmental Science, Institute for Wetland and Water Research, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands. Electronic address: A.ragas@science.ru.nl.
  • Russel FG Radboud university medical center, Department of Pharmacology and Toxicology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Frans.Russel@radboudumc.nl.
  • Scheepers PT Radboud university medical center, Department for Health Evidence, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Paul.Scheepers@radboudumc.nl.
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  • 2014-12-03
Published in:
  • Environment international. - 2015
D4
D5
Decamethylcyclopentasiloxane
End-exhaled air
Human biological monitoring
Octamethylcyclotetrasiloxane
Administration, Cutaneous
Adult
Cosmetics
Dermis
Female
Gas Chromatography-Mass Spectrometry
Humans
Inhalation Exposure
Male
Middle Aged
Risk Assessment
Siloxanes
Skin Absorption
English Consumers who use personal care products (PCPs) are internally exposed to some of the organic components present of which some may be detected in exhaled air when eliminated. The aim of this study was the quantitative determination of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air to study dermal absorption of substances in PCPs. We exposed the forearm of fifteen healthy volunteers for 60min to pure D4 or D5 and to commercial products containing D4 and D5. Inhalation uptake was kept to a minimum by keeping the forearm in a flow cabinet during dermal exposure and supplying filtered air to the breathing zone of the volunteer during the post-exposure period. End-exhaled air was collected using a breath sampler (Bio-VOC), transferred to carbograph multi-bed adsorbent tubes and analyzed by thermal desorption gas chromatography mass spectrometry (TD-GC-MS). In the end-exhaled air of non-exposed volunteers background concentrations of D4 (0.8-3.5ng/L) and D5 (0.8-4.0ng/L) were observed. After exposing the volunteers, the level of D4 and D5 in end-exhaled air did not or barely exceed background concentrations. At t=90min, a sharp increase of the D4/D5 concentration in end-exhaled air was observed, which we attributed to the inhalation of the substances during a toilet visit without using inhalation protection devices. When this visit was taken out of the protocol, the sharp increase disappeared. Overall, the results of our study indicate that dermal absorption of D4 and D5 contributes only marginally to internal exposure following dermal applications. As in our study inhalation is the primary route of entry for these compounds, we conclude that its risk assessment should focus on this particular exposure route.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/153487
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