Methods for Measuring ctDNA in Lymphomas.

Rossi D; Condoluci A; Spina V; Gaidano G

doi:10.1007/978-1-4939-8876-1_19

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Journal article

Methods for Measuring ctDNA in Lymphomas.

Rossi D Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. davide.rossi@eoc.ch.
Condoluci A Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Spina V Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland.
Gaidano G Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

2018-10-24

Published in:

Methods in molecular biology (Clifton, N.J.). - 2019

High-Throughput Nucleotide Sequencing

English Plasma cell-free DNA (cfDNA) is an easily accessible source of tumor DNA that allows accurate profiling of lymphoma patients, representing a complementary source of tumor DNA to tissue biopsy for genotyping. Applications of cfDNA analysis in lymphomas include: (1) identification of tumor mutations in a biopsy-free manner; (2) tracking tumor clonal evolution and identification of mutations causing resistance to treatment; and (3) monitoring of residual disease after therapy.

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