Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters
- Stucki, Armin Department of Internal Medicine, Inselspital, Bern, Switzerland
- Gerber, Peter Clinical of Pneumology, Inselspital, Bern, Switzerland
- Acosta, Fernando Clinical of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland
- Cottagnoud, Marianne Clinical of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland
- Cottagnoud, Philippe Department of Internal Medicine, Inselspital, Bern, Switzerland
Published in:
- Antimicrobial Agents and Chemotherapy. - American Society for Microbiology. - 2006, vol. 50, no. 2, p. 770-773
English
ABSTRACT
The penetration of telavancin was 2% into inflamed meninges and ca. 1‰ into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1128/aac.50.2.770-773.2006
- ISSN 0066-4804
- Persistent URL
- https://sonar.ch/global/documents/155
Statistics
Document views: 22
File downloads:
- Full-text: 0